Inflammatory signals drive interchromosomal contacts enabling chimeric protein production

A new study reveals that inflammation triggers physical interactions between DNA regions on different chromosomes, bringing distinct parent genes together. This proximity facilitates the generation of chimeric mRNAs that are translated into functional proteins with physiological relevance. The findings highlight a previously unknown mechanism by which inflammation can reshape gene expression and protein diversity.

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The study demonstrates that inflammatory signaling can alter the three-dimensional organization of the genome. Specifically, it induces physical proximity between DNA segments located on separate chromosomes, a rearrangement